Oral Protein Therapy for the Future –Transport of Glycolipid-Modified Proteins:Vision or Fiction?    Uploaded by: inFÁRMAte Abstract The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products and their downstream effects, including the synthesis and flux of metabolites and regulation of signalling processes. In addition, this system’s biology-driven personalized diagnosis must be accompanied by options for personalized reliable and early therapy. In the mid-term, the direct substitution or inhibition of the proteins encoded by the corresponding defective gene products of the susceptibility genes exerting lower or higher activity by administration of the ‘normal’ proteins or inhibitory antibodies, respectively, seems to be most promising. The critical hurdle of oral ...